基礎研究
腎泌尿器科基礎研究室では、泌尿器科癌、特に尿路上皮癌、腎癌、精巣腫瘍に対する分子生物学的研究並びに、トランスレーショナルリサーチを行っています。さらに、排尿障害、生殖医療、人工知能の研究にも積極的に取り組んでいます。
Major Scientific Interests of the Group
The molecular pathogenesis in urologic cancers, especially urothelial carcinoma, renal cell carcinoma and testicular tumor, and their translational research. Fields of bladder dysfunction, infertility, regenerative medicine and artificial intelligence as well.
Projects for Regular Students in Doctoral or Master’s Programs
1) Identification of novel oncogene signals and tumor immune microenvironment in urothelial cancer.
2) The effect and mechanism of ELOVL (Elongation of very long chain fatty acids) in the proliferation of renal cancer.
3) The antitumor immunity of cationized liposomal trehalose-6,6-dimycolate isolated from Mycobacterium in a syngeneic murine bladder cancer model.
4) Significance of PLD (phospholipase D) in the tumor microenvironment of bladder cancer.
5) The molecular mechanism of bladder dysfunction due to sleep/circadian rhythm disorder.
6) Detection of urologic cancer risk using serum trace elements.
Study Programs for Short Stay Students (one week – one trimester)
Clinical clerkship/Elective: surgery (robotic, laparoscopic, reduced port, open, transurethral, micro etc), clinical conference, outpatient/inpatient care and laboratory meeting.
Selected Publications of basic research
1. ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma. Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H. Oncol Rep. 2022 Feb;47(2):23. PMID: 34841437.
2. The liposome of trehalose dimycolate extracted from M. bovis BCG induces antitumor immunity via the activation of dendritic cells and CD8+ T cells. Shiga M, Miyazaki J, Tanuma K, Nagumo Y, Yoshino T, Kandori S, Negoro H, Kojima T, Tanaka R, Okiyama N, Fujisawa Y, Watanabe M, Yamasaki S, Kiyohara H, Watanabe M, Sato TA, Tahara H, Nishiyama H, Yano I. Cancer Immunol Immunother. 2021 Sep;70(9):2529-2543. PMID: 33570675.
3. PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-κB signaling in bladder cancer. Nagumo Y, Kandori S, Tanuma K, Nitta S, Chihara I, Shiga M, Hoshi A, Negoro H, Kojima T, Mathis BJ, Funakoshi Y, Nishiyama H. Cancer Lett. 2021 Jul 28;511:15-25. PMID: 33945837.
4. Cystoscopic Imaging for Bladder Cancer Detection Based on Stepwise Organic Transfer Learning with a Pretrained Convolutional Neural Network. Ikeda A, Nosato H, Kochi Y, Negoro H, Kojima T, Sakanashi H, Murakawa M, Nishiyama H. J Endourol. 2021 Jul;35(7):1030-1035. PMID: 33148020.
5. Support System of Cystoscopic Diagnosis for Bladder Cancer Based on Artificial Intelligence. Ikeda A, Nosato H, Kochi Y, Kojima T, Kawai K, Sakanashi H, Murakawa M, Nishiyama H. J Endourol. 2020 Mar;34(3):352-358. PMID: 31808367
6. TP53 codon 72 polymorphism is associated with FGFR3 and RAS mutation in non-muscle-invasive bladder cancer. Kawahara T, Kojima T, Kandori S, Kurobe M, Yoshino T, Kimura T, Nagumo Y, Ishituka R, Mitsuzuka K, Narita S, Kobayashi T, Matsui Y, Ogawa O, Sugimoto M, Miyazaki J, Nishiyama H. PLoS One. 2019 Aug 1;14(8):e0220173. PMID: 31369573
7. Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guérin induce antitumor immunity in a syngeneic murine bladder cancer model. Yoshino T, Miyazaki J, Kojima T, Kandori S, Shiga M, Kawahara T, Kimura T, Naka T, Kiyohara H, Watanabe M, Yamasaki S, Akaza H, Yano I, Nishiyama H. PLoS One. 2019 Jan 4;14(1):e0209196. PMID: 30608942
8. Systemic transduction of p16INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice. Shimazui T, Yoshikawa K, Ishitsuka R, Kojima T, Kandori S, Yoshino T, Miyazaki J, Uchida K, Nishiyama H. Oncol Lett. 2019 Jan;17(1):1203-1210. PMID: 30655885
9. Effect of TRPV4 activation in a rat model of detrusor underactivity induced by bilateral pelvic nerve crush injury. Takaoka EI, Kurobe M, Okada H, Takai S, Suzuki T, Shimizu N, Kwon J, Nishiyama H, Yoshimura N, Chermansky CJ. Neurourol Urodyn. 2018 Nov;37(8):2527-2534. PMID: 30095183
10. Phospholipase D2 promotes disease progression of renal cell carcinoma through the induction of angiogenin. Kandori S, Kojima T, Matsuoka T, Yoshino T, Sugiyama A, Nakamura E, Shimazui T, Funakoshi Y, Kanaho Y, Nishiyama H. Cancer Sci. 2018 Jun;109(6):1865-1875. PMID: 29660846
11. Development of RNA-FISH Assay for Detection of Oncogenic FGFR3-TACC3 Fusion Genes in FFPE Samples. Kurobe M, Kojima T, Nishimura K, Kandori S, Kawahara T, Yoshino T, Ueno S, Iizumi Y, Mitsuzuka K, Arai Y, Tsuruta H, Habuchi T, Kobayashi T, Matsui Y, Ogawa O, Sugimoto M, Kakehi Y, Nagumo Y, Tsutsumi M, Oikawa T, Kikuchi K, Nishiyama H. PLoS One. 2016 Dec 8;11(12):e0165109. PMID: 27930669
Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guérin induce antitumor immunity in a syngeneic murine bladder cancer model.
Circadian coordination of ATP release in the urothelium via connexin43 hemichannels.
Support System of Cystoscopic Diagnosis for Bladder Cancer Based on Artificial Intelligence.
Phospholipase D2 promotes disease progression of renal cell carcinoma through the induction of angiogenin.